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Therapeutic target discovery in ADSP data via comprehensive whole-genome analysis incorporating ethnic diversity and systems approaches

PI
Boerwinkle, Eric
DAR ID
10034
Initial Approval Date
March 5, 2019
Current DAR Status
Expired
PI Institution
University of Texas Health Science Center at Houston
PI Institution Country
United States
PI Institution Type
Non-Profit

Requested Datasets (1)

NG00067Alzheimer's Disease Sequencing Project Umbrella Study

Research Use Statement
Dr. Boerwinkle’s group is involved in all aspects of the ADSP including study design, data gathering and data analysis. Permissions are necessary for both the array genotype, DNA sequence and all available phenotype data. This availability and ensuing data access will be used for data processing and data analysis to identify novel AD risk raising and protective loci.

Non-Technical Summary
Dr. Boerwinkle’s group is involved in all aspects of the ADSP including study design, data gathering and data analysis. Permissions are necessary for both the array genotype, DNA sequence and all available phenotype data. This availability and ensuing data access will be used for data processing and data analysis to identify novel AD risk raising and protective loci.

Reported Publications (4)

Publications shown are those reported by investigators through NIAGADS DAR reporting and renewal processes and may not represent a complete list of publications associated with the project.

  1. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Bis JC, et al. Molecular psychiatry. 2020. PMID: 30108311
  2. Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer's disease sequencing project. Naj AC, et al. Genomics. 2019. PMID: 29857119
  3. Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Blue EE, et al. Dementia and geriatric cognitive disorders. 2018. PMID: 29486463
  4. Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease. Vardarajan BN, et al. Annals of clinical and translational neurology. 2018. PMID: 29688227