Searching for Alzheimer-related genetic variants and genes
- PI
- Holstege, Henne
- DAR ID
- 10060
- Initial Approval Date
- May 7, 2019
- Current DAR Status
- Active
- PI Institution
- Amsterdam UMC
- PI Institution Country
- Netherlands
- PI Institution Type
- Non-Profit
Requested Datasets (1)
Research Use Statement
The purpose of this study is to find new Alzheimer related variants and genes, by combining exome and whole genome data from healthy controls and Alzheimer patients from different studies. Data will be analyzed using association, burden and variant component statistics.
Non-Technical Summary
Some individuals develop dementia, while others do not. A large part is likely determined by ones genes, Alzheimer’s disease has a heritability of up to 80%. What are the key genetic factors that determine if one will get Alzheimer disease? In this study, we will thoroughly explore genomic data of a large group of healthy persons and dementia patients to answer this question.
Reported Publications
Publications shown are those reported by investigators through NIAGADS DAR reporting and renewal processes and may not represent a complete list of publications associated with the project.
No publications have been reported for this DAR.