Haplotype association with Alzheimer’s disease

High-throughput sequence technologies enable us to easily genotype dozens of single nucleotide polymorphisms (SNPs) within any interesting gene. Such genome-wide SNP data are rapidly growing in disease association studies. The association analysis includes single-SNP and haplotype-based disease associations. Haplotype-based association analysis has several advantages over single-SNP association analysis. We propose to develop novel statistical methods for haplotype-based association using the whole-genome sequencing data from the Alzheimer’s Disease Sequencing Project (ADSP) sponsored by the National Institute of Aging. The phenotype is the case-control status. We will use current programs for haplotyping, then use the haplotypes for genetic association studies. We will develop new methods for modeling the recombination interference.

High-throughput sequence technologies enable us to easily genotype dozens of single nucleotide polymorphisms (SNPs) within any interesting gene. Such genome-wide SNP data are rapidly growing in disease association studies. The association analysis includes single-SNP and haplotype-based disease associations. Haplotype-based association analysis has several advantages over single-SNP association analysis. We propose to develop novel statistical methods for haplotype-based association using the whole-genome sequencing data from the Alzheimer’s Disease Sequencing Project (ADSP) sponsored by the National Institute of Aging.