APOE4 and Klotho Interaction in AD
- PI
- Sadowski, Martin
- DAR ID
- 10467
- Initial Approval Date
- January 21, 2022
- Current DAR Status
- Closed
- PI Institution
- NYU School of Medicine
- PI Institution Country
- United States
- PI Institution Type
- Non-Profit
Requested Datasets (1)
Research Use Statement
Objectives of the proposed research
The objective of the proposed research is to analyze the effect of Klotho-VS heterozygosity and other genetic covariates identified during the study on the rate of Alzheimer's Disease progression as measured by neuropsychological data and brain MRI volumes in the context of the APOE genotype.
Study design
The design of this study involves the creation of a repository consisting of clinical and genetic data from the participants of the NACC's Uniform Data Set. Only participants who transitioned from a clinical diagnosis of mild cognitive impairment to Alzheimer's Disease will be considered.
Analysis plan, including the phenotypic characteristics that will be evaluated in association with genetic variant
This study will conduct a secondary analysis of the neuropsychological data (MMSE, MOCA, CDR-SB, ADAS-11) and brain MRI volumes in association with APOE genotype and other genetic predictors of clinical decline like Klotho-VS heterozygosity. Effect of Klotho-VS heterozygosity in the context of a specific APOE genotype will be determined using a linear mixed model approach comparing disease progression over time between genetic variables, as well as demographic variables such as sex and age.
There will be no collaboration with researchers at other institutions.
The objective of the proposed research is to analyze the effect of Klotho-VS heterozygosity and other genetic covariates identified during the study on the rate of Alzheimer's Disease progression as measured by neuropsychological data and brain MRI volumes in the context of the APOE genotype.
Study design
The design of this study involves the creation of a repository consisting of clinical and genetic data from the participants of the NACC's Uniform Data Set. Only participants who transitioned from a clinical diagnosis of mild cognitive impairment to Alzheimer's Disease will be considered.
Analysis plan, including the phenotypic characteristics that will be evaluated in association with genetic variant
This study will conduct a secondary analysis of the neuropsychological data (MMSE, MOCA, CDR-SB, ADAS-11) and brain MRI volumes in association with APOE genotype and other genetic predictors of clinical decline like Klotho-VS heterozygosity. Effect of Klotho-VS heterozygosity in the context of a specific APOE genotype will be determined using a linear mixed model approach comparing disease progression over time between genetic variables, as well as demographic variables such as sex and age.
There will be no collaboration with researchers at other institutions.
Non-Technical Summary
Gene set which controls the rate of Alzheimer's disease (AD) progression both in terms of accelerating and attenuating its rate is unknown. Our recently published work demonstrated feasibility of statistical modeling of longitudinal clinical data from AD patients to uncover the effect of certain genes on the rate of disease progression. Thus, we showed that AD patients who harbor the e4 allele of apolipoprotein E gene show accelerates clinical course of AD in comparison to e4 non-carriers. In this project we plant to use statistical modeling of longitudinal clinical data to correlate trajectory of disease progression in with their individual genetic makeup. A gene which effect on AD progression were are planning to study next is Klotho-VS heterozygosity.
Reported Publications
Publications shown are those reported by investigators through NIAGADS DAR reporting and renewal processes and may not represent a complete list of publications associated with the project.
No publications have been reported for this DAR.