Meta-analysis of AD
- PI
- Stefansson, Hreinn
- DAR ID
- 10982
- Initial Approval Date
- May 30, 2024
- Current DAR Status
- Expired
- PI Institution
- deCODE genetics
- PI Institution Country
- Iceland
- PI Institution Type
- For-Profit
Requested Datasets (1)
Research Use Statement
The data will undergo meta-analysis, combining it with another extensive whole-genome sequenced Alzheimer's project encompassing participants from Iceland, Denmark, Norway, Sweden, and the UK. Our analysis will specifically concentrate on the identification of rare sequence variants with significant impact, utilizing burden analysis and investigating loci associated with risk through a recessive mode of inheritance. By pooling these datasets, we hope to gain further insights into the genetic architecture of Alzheimer's disease, shedding light on rare variants and potential recessive risk factors. Our main focus will be on genetics of Alzheimer's disease (G30* + F00*).
Non-Technical Summary
The data will undergo meta-analysis, combining it with another extensive whole-genome sequenced Alzheimer's project encompassing participants from Iceland, Denmark, Norway, Sweden, and the UK. Our analysis will specifically concentrate on the identification of rare sequence variants with significant impact, utilizing burden analysis and investigating loci associated with risk through a recessive mode of inheritance. By pooling these datasets, we hope to gain further insights into the genetic architecture of Alzheimer's disease, shedding light on rare variants and potential recessive risk factors.
Reported Publications
Publications shown are those reported by investigators through NIAGADS DAR reporting and renewal processes and may not represent a complete list of publications associated with the project.
No publications have been reported for this DAR.