Defining the unique immunogenetic landscape of PSP compared to related dementias
- PI
- Rexach, Jessica
- DAR ID
- 11288
- Initial Approval Date
- October 25, 2024
- Current DAR Status
- Active
- PI Institution
- University of California, Los Angeles
- PI Institution Country
- United States
- PI Institution Type
- Non-Profit
Requested Datasets (2)
Research Use Statement
Objective: This research centers on the investigation of the genetic aspects of Progressive Supranuclear Palsy (PSP) compared to Alzheimer's Disease (AD) and unaffected controls through the analysis of whole genome sequencing data. The objective of this study is to comprehensively analyze the immunogenetic landscape in PSP and AD individuals compared to a control group in this dataset.
Non-Technical Summary
In our study, we aim to decipher the genetic underpinnings of Progressive Supranuclear Palsy (PSP) related to immune function. We will use sequencing data to run genomics analyses that are focused on a specific region of DNA called the HLA locus and additional immune genes, which play crucial roles in our immune system. Our goal is to compare the genetic makeup of the HLA locus in people affected by PSP compared to those with Alzheimer’s disease (AD) and the general population. In simple terms, we're looking for clues in the DNA that could explain how changes in the immune system might influence why some individuals develop these conditions.
Reported Publications
Publications shown are those reported by investigators through NIAGADS DAR reporting and renewal processes and may not represent a complete list of publications associated with the project.
No publications have been reported for this DAR.