Genomic and social determinants of cognitive decline and resilience in the Health and Retirement Study
- PI
- Hu, William
- DAR ID
- 11309
- Initial Approval Date
- June 28, 2024
- Current DAR Status
- Active
- PI Institution
- Rutgers Institute for Health, Health Care Policy, and Aging Research
- PI Institution Country
- United States
- PI Institution Type
- Non-Profit
Requested Datasets (1)
Research Use Statement
Both positive (social engagement, leisurely activities) and negative (isolation, widowhood) social determinants
have been identified to influence cognitive decline in the Health and Retirement Study, but known genetic risk factors for Alzheimer’s disease, cardiovascular disease, and frailty are often not taken into account. Leveraging the expertise of the Asian Resource Center for Minority Aging Research, we propose to examine impact of introducing genomic markers into our current models linking social determinants and cognitive decline, and identify interactions predictive of vulnerability as well as resilience to cognitive decline
have been identified to influence cognitive decline in the Health and Retirement Study, but known genetic risk factors for Alzheimer’s disease, cardiovascular disease, and frailty are often not taken into account. Leveraging the expertise of the Asian Resource Center for Minority Aging Research, we propose to examine impact of introducing genomic markers into our current models linking social determinants and cognitive decline, and identify interactions predictive of vulnerability as well as resilience to cognitive decline
Non-Technical Summary
People’s behaviors can contribute to or compensate for genetic risks for age-related conditions such as dementia
and frailty, and we will identify positive and negative behaviors associated with genetic risks for Alzheimer’s disease and related conditions.
and frailty, and we will identify positive and negative behaviors associated with genetic risks for Alzheimer’s disease and related conditions.
Reported Publications
Publications shown are those reported by investigators through NIAGADS DAR reporting and renewal processes and may not represent a complete list of publications associated with the project.
No publications have been reported for this DAR.