Alzheimer’s Disease Sequencing Project Coordinating Center

The Alzheimer’s Disease Sequencing Project Coordinating Center (ADSP CC) is requesting access to the ADSP umbrella dataset and related data to support the CC’s general aims of scientific and administrative support of the ADSP. We propose to:

1. Analyze the molecular and/or phenotype data to identify potential collaborative research projects and develop appropriately protected data sets for ADSP-related training opportunities or workshops to advance the ADSP’s programmatic goals.
2. Analyze (or provide input on analysis plans of) molecular and/or phenotype data to generate resources such as QC filters/metrics, ancestry PCs, local ancestry inference, relatedness measures, annotations, standardized phenotypes.
3. Explore the creation of an ADSP catalog with summaries of available data and resources shared with the scientific community to facilitate discovery and use of ADSP data. This catalog would be limited to summary-level information that can be shared publicly.
4. Complete a landscape analysis of ADSP and related data, including data formats, elements, and documentation that are behind access control, and identify opportunities to support data interoperability and partnerships with other AD/ADRD research programs. This could aid us to develop and implement a data model that defines standards and structure for data and metadata.
5. Investigate feasibility of performing analyses of ADSP data in secure, NIH-designated cloud-based platforms that meet the NIH Security Best Practices for Users of Controlled-Access Data (see Cloud Use Statement and Cloud Server Provider Information).

Accessors will not use the requested data to investigate individual identity in any analyses. Consent and other Data Use Limitations (DUL) for each study will be respected in all analyses.

This application will support collaboration between ADSP CC investigators at the University of Washington and MPIs Anita DeStefano and Michael Hawrylycz.

The Alzheimer’s Disease Sequencing Project Coordinating Center (ADSP CC) will characterize and analyze the available ADSP and related data to facilitate broader use of this valuable resource. The CC’s activities will include developing documentation, analysis resources, and training materials.