NG00020 – NIA AD-FBS GWAS

The goal of the National Institute of Aging Alzheimer’s Disease Family Based Study, NIA AD-FBS (formerly National Institute on Aging Genetics Initiative for Late-Onset Alzheimer’s Disease, NIA-LOAD) is to identify and recruit families with two or more siblings with the late-onset form of Alzheimer’s disease and a cohort of unrelated, non-demented controls similar in age and ethnic background, and to make the samples, the clinical and genotyping data and preliminary analyses available to qualified investigators world-wide.

Genotyping done by the Center for Inherited Disease Research (CIDR) was performed using the Illumina Infinium II assay protocol with hybridization to Illumina Human 610Quadv1_B Beadchips. When first deposited in 2012, this genotyping represented the largest collection of families ever assembled with Alzheimer’s disease combining the NIA-LOAD Genetics Initiative Multiplex Family Study, the National Cell Repository for Alzheimer’s Disease (NCRAD) with additional controls from the NIA Alzheimer’s Disease Research Centers (ADRC).

A subset of unrelated cases and controls which contains PLINK genotype files that have undergone ADGC quality control procedures, covariates formatted by ADGC to be used with the genotype data, and imputation files (.bgen format) generated using the TOPMED-r2 reference panel is available for request in dataset NG00032.