To access this data, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00059) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.

This dataset was originally published on the NIAGADS archive site and was moved to DSS on 09/11/26.

Description

The Aging, Dementia and Traumatic Brain Injury Study is a detailed neuropathologic, molecular and transcriptomic characterization of brains of control and TBI exposure cases from a unique aged population-based cohort from the Adult Changes in Thought (ACT) study. This study was developed by a consortium consisting of the University of Washington, Kaiser Permanente Washington Health Research Institute, and the Allen Institute for Brain Science, and was supported by the Paul G. Allen Family Foundation.

This freely available resource (http://aging.brain-map.org/) presents a systematic and extensive data set of study participant metadata, quantitative histology and protein measurements of neuropathology, and RNA sequencing (RNA-seq) analysis of hippocampus and neocortex. In total, 377 samples collected from cortical grey (parietal and temporal) and white matter (parietal) and hippocampus from a total of 107 brains are presented in this resource.

Phenotypes are available for download through the Aging, Dementia, and TBI Study website here, http://aging.brain-map.org/download/index.

Sample Summary per Data Type

Sample SetAccessionData TypeNumber of Samples
Aging, Dementia, and TBI Study: RNASeq Datasetsnd10148Short-Read RNA Sequencing377

Available Filesets

NameAccessionLatest ReleaseDescription
AllenAgingDementiaTBI: RNASeq Datafsa000182NG00059.v1RNASeq Data

View the File Manifest for a full list of files released in this dataset.