Overview
To access this data, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00095) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.
Description
The Religious Orders Study (ROS) and Memory and Aging Project (MAP) are two community-based cohort studies. The Religious Orders Study and the Rush Memory and Aging Project are both cohort studies of aging and dementia that include organ donation at death. Together, more than 2,700 persons have agreed to annual clinical evaluation and brain donation at death.
This SNP array dataset, ROSMAP2, was used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here are the PLINK genotype files that have undergone ADGC quality control procedures, covariates formatted by ADGC to be used with the genotype data, and imputation files (.bgen format) generated using the TOPMED-r2 reference panel. Additional phenotypic data can be requested through the Rush RADC: https://www.radc.rush.edu/requests.htm.
Sample Summary per Data Type
| Sample Set | Accession | Data Type | Number of Samples |
|---|---|---|---|
| ROSMAP2 GWAS | snd10135 | Genotyping SNP Array | 533 |
Available Filesets
| Name | Accession | Latest Release | Description |
|---|---|---|---|
| ROSMAP2 GWAS: Genotype, covariate, and imputation files. | fsa000169 | NG00095.v1 | Genotype, covariate, and imputation files. |
View the File Manifest for a full list of files released in this dataset.