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Within the application, add this dataset (accession NG00134) in the “Choose a Dataset” section.
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A dried blood spot (DBS) collection in Round 7 (2017) of NHATS provided the biological material for genotyping. Samples were genotyped at Erasmus Medical Center in Rotterdam, Netherlands on the Illumina Infinium Global Screening Array v3.0. The array contains clinical and rare variants ideal for multiethnic populations. After quality control steps removing variants with high (>5%) missingness and individuals with high missingness (>5%), a total of 700,009 variants and 4,006 samples were included in the NHATS genetic dataset. Quality control was performed at the Arking Lab at the Johns Hopkins University and validated independently at the University of Michigan. We include genotyped data (build hg19/GRCh37 plink format), TOPMed imputed data (build GRCh38, vcf format), ancestry-specific analytic groups, as well as recommended sample filtering information. Within ancestry principal components are available from the NHATS study by request.
Self-reported primary race/ethnicity with missing values assigned the modal category indicated 729 non-Hispanic Black, 2,962 non-Hispanic White, 223 Hispanic, and 92 other race/ethnicity samples (see population breakdown below). For detail about each self-reported race/ethnicity group see the NHATS User Guide [https://nhats.org/researcher/nhats/methods-documentation?id=user_guide]. To request phenotype data for participants in this study, apply at https://www.nhats.org/researcher/data-access/sensitive-data-files?id=restricted_data_files
Sample Summary per Data Type
|Sample Set||Accession||Data Type||Number of Samples|
|National Health & Aging Trends Study (NHATS) GWAS||snd10042||GWAS||4,006|
|NHATS GWAS: Genotype data||fsa000044||NG00134.v1||Genotype data|
|NHATS GWAS: TOPMed imputation data||fsa000045||NG00134.v1||TOPMed imputation data|
View the File Manifest for a full list of files released in this dataset.
Provided in this dataset is a set of GWAS files that underwent a process of quality control measures by the Arking Lab at the Johns Hopkins University, as well as imputed genotypes from the TOPMed reference panel. 4,006 subjects were genotyped at the Erasmus Medical Center in Rotterdam, Netherlands on the Illumina Infinium Global Screening Array v3.0, which captures genotype data on 700,009 genomic SNPs.
|Sample Set||Accession Number||Number of Subjects|
|National Health & Aging Trends Study (NHATS) GWAS||snd10042||4,006|
|Consent Level||Number of Subjects|
Visit the Data Use Limitations page for definitions of the consent levels above.
Acknowledgment statement for any data distributed by NIAGADS:
Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.
Use the study-specific acknowledgement statements below (as applicable):
For investigators using any data from this dataset:
Please cite/reference the use of NIAGADS data by including the accession NG00134.
For investigators using NHATS (sa000030) data:
In text: “National Health and Aging Trends Study (NHATS) is sponsored by the National Institute on Aging (grant number NIA U01AG32947) and conducted by the Johns Hopkins University.”
In references: “National Health and Aging Trends Study. Produced and distributed by www.nhats.org with funding from the National Institute on Aging (grant number NIA U01AG32947).”