Overview
To access this data, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00146) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.
Description
This dataset includes individual level data from Singapore-Longitudinal study of Vascular Cognitive Impairment and Dementia. This includes both genotyping (raw and imputed) on the Infinium Global Screening Array-24 Kit as well as phenotypic data including age, sex, and overall cognitive diagnosis. There were total of 390 subjects that were enrolled in the study and 385 subjects passed QC filtering.
Participants were recruited from memory clinics in 2 study sites in Singapore (National University Hospital and Saint Luke’s Hospital). Four diagnostic categories at baseline were eligible for inclusion in this study:(1) No cognitive impairment (NCI): individuals who had no objective cognitive impairment on neuropsychological tests, or functional loss, (2) Cognitive impairment no dementia (CIND) was diagnosed in patients who were impaired in at least one cognitive domain on a neuropsychological test battery without loss of daily functions. (3) Vascular CIND was defined as a history of ischemic stroke within the past 6–24 months and neuroimaging evidence of cerebral infarction, with objective evidence of neuropsychological deficits. (4) Dementia was diagnosed according to Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) criteria.
Sample Summary per Data Type
| Sample Set | Accession | Data Type | Number of Samples |
|---|---|---|---|
| Singapore GWAS | snd10047 | Genotyping SNP Array | 390 |
Available Filesets
| Name | Accession | Latest Release | Description |
|---|---|---|---|
| Singapore GWAS: Genotype, phenotype and Imputation data | fsa000064 | NG00146.v1 | Genotype, Phenotype and Imputation data |
View the File Manifest for a full list of files released in this dataset.