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Description

Plasma samples were obtained from the Knight-ADRC at Washington University in Saint Louis repositories. This is a deeply phenotyped cohort, both clinically and molecularly with longitudinal data and samples available. We included 32 samples from healthy non-demented control participants, 45 samples from presymptomatic AD participants and 53 samples from symptomatic AD participants. All AD participants were required to have evidence of Aβ deposition (CSF Aβ<500ng/L), positive PET scan and/or evidence of clinical worsening measured by CDR® from the time at draw to the last clinical visit. We also included participants from other neurodegenerative diseases: 20 DLB participants and 18 FTD participants. All participants were diagnosed in accordance with clinical criteria that are embodied in the Uniform Data Set (UDS), the standard clinical data set that is collected in all participants who are enrolled in all of the 37-federally funded ADRCs. This research was conducted in accordance with the recommended protocols. Written informed consent was obtained from all participants or their family members. The dataset consists of raw sRNA sequencing data and a supporting phenotype file.

Sample Summary per Data Type

Sample SetAccessionData TypeNumber of Samples
Plasma Small RNA Transcriptomics ADRD snd10127Small RNA Sequencing168

Available Filesets

NameAccessionLatest ReleaseDescription
Plasma Small RNA Transcriptomics ADRDfsa000150NG00168.v1Fastq Files, Phenotypes, Readme

View the File Manifest for a full list of files released in this dataset.