To access the full dataset, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00172) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.

The p-value only files are available in the “Open Access Dataset” tab.

Description

Participants for this analysis were selected with whole-genome sequencing at 30x coverage from the Alzheimer’s Disease Sequencing Project dataset (ADSP, ng00067.v7). Included were 1,834 PSP cases and 128 controls from the PSP-NIH-CurePSP-Tau, PSP-CurePSP-Tau, PSP-UCLA, and AMPAD-MAYO cohorts as well as 3,008 controls from other cohorts in the ADSP dataset. For association analysis, linear mixed model implemented in R Genesis were used. Genetic relatedness matrix was obtained using KING. PCs were obtained by PC-AiR which accounts for sample relatedness. Sex and PC1-5 were adjusted in the linear mixed model. Age was not adjusted as more than half (1,159 of 1,718) of PSP cases had age missing.

Available Filesets

NameAccessionLatest ReleaseDescription
GWAS Summary Statistics of SNVs/INDELs/SVs for PSP: Full Summary Statistics (application needed)fsa000114NG00172.v1Full Summary Statistics
GWAS Summary Statistics of SNVs/INDELs/SVs for PSP: p-values Only (open access)fsa000115NG00172.v1p-values Only

View the File Manifest for a full list of files released in this dataset.