To access the full dataset, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00175) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.

The p-value only files are available in the “Open Access Dataset” tab.

Description

This dataset includes summary statistics for a genome-wide association study meta-analysis of eleven neuropathology endophenotypes. Included neuropathology endophenotypes are neuritic plaques, tau neurofibrillary tangles, cerebral amyloid angiography, amyloid-beta plaques, TDP-43 deposits, Lewy body deposits, cerebral atherosclerosis, cerebral arteriolosclerosis, gross infarcts, microinfarcts, and hippocampal sclerosis. The individual studies used in this project were National Alzheimer’s Coordinating Center (NACC), Religious Orders Study (ROS) and Rush Memory and Aging Project (MAP), and Adult Changes in Thought (ACT; n =7,804 total autopsied participants across all four studies). Each study was analyzed individually (ROS and MAP were analyzed together) with meta-analysis being subsequently performed.

Available Filesets

NameAccessionLatest ReleaseDescription
Neuropathology Endophenotypes GWAS; Full Summary Statistics (application needed)fsa000145NG00175.v1Full Summary Statistics
Neuropathology Endophenotypes GWAS; P-Value Only (open access)fsa000146NG00175.v1P-value Only

View the File Manifest for a full list of files released in this dataset.