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Within the application, add this dataset (accession NG00177) in the “Choose a Dataset” section.
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The p-value only files are available in the “Open Access Dataset” tab.

Description

Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in ancestry groups of predominantly non-European ancestral backgrounds in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry collection of GWAS datasets in the Alzheimer’s Disease Genetics Consortium (ADGC) to test for novel shared and population-specific late-onset Alzheimer’s Disease (LOAD) susceptibility loci. We evaluated the underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6,728 African American, 8,899 Hispanic (HIS), and 3,232 East Asian individuals, performing within ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis. All Cases met either NINCDS-ADRDA Working Group (McKhann et al 1984; PMID: 6610841) or NIA-AA Working Group (PMID: 21514250) criteria for clinical AD diagnoses or have autopsy-confirmed disease and have diagnosis after age 60 years. All non-cases/controls were cognitively intact, with an MMSE>28 and at least 60 years of age at their last exam; or were deceased after age 60 and free of cognitive complaint prior to death or have autopsy-confirmation of limited AD pathology.

Available Filesets

NameAccessionLatest ReleaseDescription
ADGC Multi-Ancestry GWAS Meta-Analysis Summary Statistics (application needed)fsa000141NG00177.v1Full Summary Statistics
ADGC Multi-Ancestry GWAS Meta-Analysis P-values only (open access)fsa000142NG00177.v1P-values Only

View the File Manifest for a full list of files released in this dataset.