All data provided in this dataset are open access and are available publicly in the “Open Access Dataset” tab.

Description

To build ancestry-stratified genetic maps of the plasma proteome and metabolome, we performed pQTL and metabolite-QTL (mQTL) analyses on participants of African and European ancestry from Knight-ADRC cohort separately.  We utilized an aptamer-based assay (SomaScan 7k platform) to measure protein levels and a mass-spectrometry assay (Metabolon HD4 platform) to quantify the metabolite levels. The proteomic and metabolomic datasets were generated from the same cohort.  Following quality control procedures for the omics data and integration with array-based post-imputation genotype data, we constructed four maps/atlases: i) AFR pQTL (414 participants and 6,907 proteins), ii) EUR pQTL (2,338 participants and 6,907 proteins), iii) AFR mQTL (417 participants and 1,413 metabolites), and iv) EUR mQTL (2,392 participants and 1,483 metabolites).

In total, 3,170 participants from all genetic ancestries were selected for both proteomics and metabolomics profiling.  The plasma proteomic and metabolomic datasets were generated from participants, which included 1,254 AD patients, 1,720 healthy controls, 34 frontotemporal dementia patients, and 162 individuals with an unclassified neurodegenerative disease.  The dataset consists of GWAS summary statistics (GRCh38) for all 16,710 traits (EUR-proteins: 6.907; AFR-proteins: 6,907; EUR-metabolites: 1,483; AFR-metabolites: 1,413).

Available Filesets

NameAccessionLatest ReleaseDescription
KGAD EUR AFR QTL: Full summary statisticsfsa000148NG00180.v1Full summary statistics

View the File Manifest for a full list of files released in this dataset.