Overview
The p-value only files are available in the “Open Access Dataset” tab.
To access the full data, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00191) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.
Description
We performed a GWAS meta-analysis including 18,948 individuals of European ancestry. This is the largest study to date for the three biomarkers encompassing 30 different studies. Biomarker levels from 6,785 participants across 22 studies were combined into a single dataset using a z-score based data standardization (mean 0 and variance 1 within each cohort) and analyzed at Washington University in St. Louis Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC). The summary statistics from this dataset were then meta-analyzed with summary statistics from eight cohorts : European Alzheimer’s and Dementia Biobank (EADB, N=7,516), The European Prevention of Alzheimer’s Dementia (EPAD, N=1,370), Ace Alzheimer Center Barcelona (ACE, N=1,302), European Medical Information Framework for Alzheimer’s Disease (EMIF-AD, N=670), MISSION-AD (N=462, Eisai), Janssen cohorts 1 and 2 (Janssen, N=457) and Alzheimer’s and Families cohort (ALFA+ study, N=386).This dataset consists of METAL summary statistics (GRCh38) for the three biomarkers obtained at the end of meta-analysis.
Available Filesets
| Name | Accession | Latest Release | Description |
|---|---|---|---|
| CSF GWAS Meta: Full Summary Statistics (application needed) | fsa000183 | NG00191.v1 | Full Summary Statistics |
| CSF GWAS Meta: P-values only (open access) | fsa000184 | NG00191.v1 | P-values only |
View the File Manifest for a full list of files released in this dataset.