Description
The project goal is to perform whole-genome sequencing (WGS) on Alzheimer’s disease (AD) cases to identify both common and uncommon variants associated with AD-related phenotypes (e.g., disease progression, survival time). All subjects were Caucasians with probable or possible having age at onset of 60 or above. Whole-genome sequencing was performed using Illumina HiSeqX.
Related Publications
- Kamboh MI. Genome-wide association analysis of age-at-onset in Alzheimer's disease. Molecular psychiatry. 2012 Dec. PubMed link
- Kamboh MI. Genome-wide association study of Alzheimer's disease. Translational psychiatry. 2012 May 15. PubMed link
- Wang X. Genetic determinants of disease progression in Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2015. PubMed link
- Fan KH. Whole-Exome Sequencing Analysis of Alzheimer's Disease in Non-APOE*4 Carriers. Journal of Alzheimer's disease : JAD. 2020. PubMed link