Identification of the plasma proteomic changes of Coronavirus disease 2019 (COVID-19) is essential to understanding the pathophysiology of the disease and developing predictive models and novel therapeutics.  There are no large-scale efforts to study the plasma proteomic alterations due to COVID-19. We obtained high throughput plasma proteomic data using SomaScan 7K for a large cohort of 482 individuals. We recruited 332 COVID-19 patients with positive SARS-CoV-2 test from March 26, 2020 to September 30, 2020 at Barnes Jewish Hospital, St. Louis Children’s Hospital or affiliated Barnes Jewish Hospital testing sites in St. Louis. We obtained the ventilation status and death status from the hospital records. Using plasma samples collected prior to November 2019, we selected 150 controls by matching on sex, race and age. 


The data including phenotype and plasma proteomic data was generated at Washington University in St. Louis.

Additional information about Knight ADRC datasets available through NIAGADS can be found on the Knight ADRC Collection page.