This project provides exome, genome, and genotyping SNP array data (both pre-imputation and post-imputation) for the University of Alabama at Birmingham (UAB) Alzheimer’s Disease Research Center. Participants are enrolled as either cognitively unimpaired, MCI, or a target of mild dementia and followed longitudinally. The cohort aims to recruit a substantial fraction of self-reported African American / Black participants.
HudsonAlpha Institute for Biotechnology
Erik Roberson, MD,PhD
The University of Alabama Birmingham
This study is supported by a research grant from the US National Institute on Aging, Grant 5P20AG068024.
Acknowledgment statement for any data distributed by NIAGADS:
Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.
For investigators using University of Alabama at Birmingham Alzheimer’s Disease Research Center data:
Funding for genome sequencing was provided by the HudsonAlpha Memory and Mobility program. Funding for exome sequencing was provided by the Alzheimer’s Association. Funding for array genotyping was provided by NIA grant 5P20AG068024.
Wright AC., et al. Contributions of rare and common variation to early-onset and atypical dementia risk. medRxiv. 2023 Feb 8. doi:10.1101/2023.02.06.23285383.Pubmed Link