Description
The Healthy Elderly Active Longevity Study, nicknamed the “Wellderly” Study, began enrollment in 2007 and focuses on understanding the genetic components of healthy aging.
The objective of this study is to obtain blood and/or saliva samples in order to help model health and disease phenotypes through population genomics. Initially enrollment was open to individuals 80 years of age or older, but was later raised to 85 years of age and older.
Individuals enrolled into the study must be healthy or may have mild medical conditions associated with the normal aging process. Phenotypic information collected includes basic demographic information such as birthdate, height and weight at time of enrollment. It also includes data on alcohol use, tobacco use, exercise, highest level of education, the birthplace of their grandparents, prescription medications used, any activities of daily living they require assistance with; any chronic conditions (which are accepted in the study inclusion criteria) and lastly the date of their last physical exam.
Related Publications
- Tewhey R. Enrichment of sequencing targets from the human genome by solution hybridization. Genome biology. 2009. PubMed link
- Cruchaga C. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. 2014 Jan 23. PubMed link
- Erikson GA. SG-ADVISER CNV: copy-number variant annotation and interpretation. Genetics in medicine : official journal of the American College of Medical Genetics. 2015 Sep. PubMed link
- Pham PH. Scripps Genome ADVISER: Annotation and Distributed Variant Interpretation SERver. PloS one. 2015. PubMed link
- Erikson GA. Whole-Genome Sequencing of a Healthy Aging Cohort. Cell. 2016 May 5. PubMed link
- Bandres-Ciga S. Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease. Acta neuropathologica. 2020 Sep. PubMed link
- Dewan R. Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Neuron. 2021 Feb 3. PubMed link
- Weißbach S. Reliability of genomic variants across different next-generation sequencing platforms and bioinformatic processing pipelines. BMC genomics. 2021 Jan 19. PubMed link