A GWAS meta-analysis of 2,784 cases and 5,222 controls recruited from several case-control and family-based studies of African Americans was performed.  A detailed description of the original cohorts and summary demographics of all samples included in this analysis are provided in the Supplementary Material of Kunkle et al. (Supplementary Note; Supplementary Tables 1-3). Imputation was performed with the African Genome Resources (AGR) panel (https://www.apcdr.org/data/),The final SNP set for analysis included 29,610,185 genotyped and imputed variants. Genotype dosages were analyzed within each dataset and subsequently meta-analyzed, adjusting for age, sex and PCs for population substructure (Model 1), and subsequently in addition for APOE genotype (Model 2). Additional details on these analyses and the methods for gene, pathway and expression association analyses can be found in the Supplementary Material of Kunkle et al.