Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. Kunkle et al. (2021)

Description

A GWAS meta-analysis of 2,784 cases and 5,222 controls recruited from several case-control and family-based studies of African Americans was performed.  A detailed description of the original cohorts and summary demographics of all samples included in this analysis are provided in the Supplementary Material of Kunkle et al. (Supplementary Note; Supplementary Tables 1-3). Imputation was performed with the African Genome Resources (AGR) panel (https://www.apcdr.org/data/),The final SNP set for analysis included 29,610,185 genotyped and imputed variants. Genotype dosages were analyzed within each dataset and subsequently meta-analyzed, adjusting for age, sex and PCs for population substructure (Model 1), and subsequently in addition for APOE genotype (Model 2). Additional details on these analyses and the methods for gene, pathway and expression association analyses can be found in the Supplementary Material of Kunkle et al.

Principal Investigators

Brian Kunkle — University of Miami
Christiane Reitz — Columbia University

Funding Sources

U01 AG032984

Publications

Kunkle BW. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA neurology. 2021 Jan 1. PubMed link

Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

For investigators using Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. Kunkle et al. (2021)) data:

The Kunkle et al. ADGC African American GWAS meta-analysis was supported by NIH grants: RF1 AG054023, U24 AG056270, ADGC - U01 AG032984, NIA-LOAD – U24 AG026395, U24 AG026390 (PI Richard Mayeux, MD), NIAGADS – U24 AG041689 (PI Li-San Wang, PhD), WHICAP – R01 AG037212, R37 AG015473 (PI Richard Mayeux, MD), NCRAD -  U24 AG021886 (PI Tatiana Foroud, PhD), Indianapolis AA – R01 AG009956, RC2 AG036650 (PI Kathleen Hall, PhD), ACT – U01 AG06781, U01 HG004610 (PI Eric Larson, MD, MPH), MIRAGE – R01 AG009029 (PI Lindsay Farrer, PhD), GenerAAtions – 5R01 AG20688 (PI M. Daniele Fallin, PhD), Pittsburg – P50 AG005133 (PI O. Lopez), AG030653, AG041718, AG064877 (PI M. Ilyas Kamboh, PhD), Case Western Reserve University – R01 AG019085 (PI Jonathan Haines, PhD), CHAP – R01 AG11101, R01 AG030146, RC2 AG036650 (PI Denis Evans, MD), ROS/MAP - P30 AG10161, R01 AG15819, R01 AG30146, R01 AG17917, R01 AG15819 (PI David Bennett, MD), African-American AD Genetics Study – R01 AG028786 (PI Jennifer Manly, PhD), MARS/CORE – R01 AG22018, P30 AG10161 (PI Lisa Barnes, PhD), Mayo – P50 AG0016574, R01 032990, KL2 RR024151 (PIs Ronald C. Petersen, MD, PhD, Nilufer Ertekin-Taner, MD, PhD and Neill Graff-Radford, MD), Miami – R01 AG027944, R01 AG028786 (PI Margaret Pericak-Vance, PhD), Wake Forest (PI Goldie Byrd, PhD), MSSM (PI Joseph Buxbaum, PhD) and MSSM – P50 AG05681, P01 AG03991, P01 AG026276 (PI Alison Goate). CR was further supported by NIH grants (RF1AG054080, U01AG052410, AG0087202). The NACC database is funded by NIA/NIH Grant U01 AG016976. NACC data are contributed by the NIA-funded ADCs: P30 AG019610 (PI Eric Reiman, MD), P30 AG013846 (PI Neil Kowall, MD), P30 AG062428-01 (PI James Leverenz, MD) P50 AG008702 (PI Scott Small, MD), P50 AG025688 (PI Allan Levey, MD, PhD), P50 AG047266 (PI Todd Golde, MD, PhD), AG045058 (PI Thomas Obisesan, MD, MPH), P30 AG010133 (PI Andrew Saykin, PsyD), P50 AG005146 (PI Marilyn Albert, PhD), P30 AG062421-01 (PI Bradley Hyman, MD, PhD), P50 AG005138 (PI Mary Sano, PhD), P30 AG008051 (PI Thomas Wisniewski, MD), P30 AG013854 (PI Robert Vassar, PhD), P30 AG008017 (PI Jeffrey Kaye, MD), P30 AG010161 (PI David Bennett, MD), P50 AG047366 (PI Victor Henderson, MD, MS), P30 AG010129 (PI Charles DeCarli, MD), P50 AG016573 (PI Frank LaFerla, PhD), P30 AG062429-01(PI James Brewer, MD, PhD), P50 AG023501 (PI Bruce Miller, MD), P30 AG035982 (PI Russell Swerdlow, MD), P30 AG028383 (PI Linda Van Eldik, PhD), P30 AG053760 (PI Henry Paulson, MD, PhD), P30 AG010124 (PI John Trojanowski, MD, PhD), P50 AG005133 (PI Oscar Lopez, MD), P50 AG005142 (PI Helena Chui, MD), P30 AG012300 (PI Roger Rosenberg, MD), P30 AG049638 (PI Suzanne Craft, PhD), P50 AG005136 (PI Thomas Grabowski, MD), P30 AG062715-01 (PI Sanjay Asthana, MD, FRCP), P50 AG005681 (PI John C. Morris, MD), P50 AG047270 (PI Stephen Strittmatter, MD, PhD).