Description

Neuropsychiatric symptoms in dementia (NPS) collectively refer to behavioral and psychological symptoms affecting individuals with mild cognitive impairment (MCI) or Alzheimer’s disease or related dementia (ADRD). To investigate genetic variants contributing to NPS, we performed a genome-wide association study (GWAS) for nine NPS domains measured by the Neuropsychiatric Symptom Inventory Questionnaire (NPI-Q) in ~12,800 participants from Alzheimer’s Disease Research Centers across the United States. All participants had MCI or dementia and were of European genetic ancestry.

Principal Investigators

  • Aliza P. Wingo — University of California, Davis; VA Northern California Healthcare System
  • Thomas S. Wingo — University of California, Davis

Funding Sources

1R01MH118233; T32 HG008341; R01AG075827, R01AG072120, R01AG079170

Publications

  • Vattathil SM. GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2025 Jun. PubMed link