Corticobasal degeneration (CBD) is a rare neurodegenerative disorder of unknown etiology. The genetics of CBD are largely unknown. To identify genes and rare variants that cause or increase risk for CBD, this study generated whole exome sequence (WES) data for 384 autopsy-documented CBD cases. The Center for Applied Genomics (CAG) at the Children’s Hospital of Philadelphia performed library preparation and WES using the SureSelect XT automated library preparation, the v5 Agilent SureSelect kit, and sequencing run performed as Paired End, 2×125 on the Hiseq2500. WES data was processed using the Alzheimer’s Disease Sequencing Project (ADSP) protocol for quality control procedures and for generating a project level variant call format file (VCF).