Description
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with many biological processes, and molecular changes. The etiology of AD is complex and not specific to a single genetic factor. Epigenetic changes could help explain the missing heritability not capture in GWAS chips and determine functional variants in genome-wide significant loci. DNA methylation data from 431 parietal lobe of AD and neuropath-free controls was generated from the Knight-ADRC. The Illumina Infinium MethylationEPIC interrogates the methylation over 850,000 CpG and non-CpG sites, open chromatin, enhancers, DNase hypersensitive sites and promoters.
Sex
Total number of samples: 431
Female 256 59.4 %
Male 174 40.4 %
Race
Total number of samples: 431
| American Indian/Alaska Native | 1 |
| Black or African American | 17 |
| White | 413 |
Ethnicity
Total number of samples: 431
Not Hispanic or Latino
89
20.6%
Hispanic or Latino
1
0.2%
Not Applicable/Not Available
341
79.1%
Diagnosis
Total number of samples: 431
| Alzheimer's Disease and Related Dementias (ADRD) | ||
|---|---|---|
| Control | 35 | 8.1% |
| Case | 383 | 88.9% |
| Other | 12 | 2.8% |
| NA | ||
|---|---|---|
| Unknown | 1 | 0.2% |
APOE
Total number of samples: 431
- 2322 (5.1%)
- 2420 (4.6%)
- 33181 (42.0%)
- 34167 (38.7%)
- 4437 (8.6%)
- 4 (0.9%)