Overview
All data provided in this dataset are open access and are available publicly in the “Open Access Dataset” tab.
Description
Cis-expression quantitative trait loci (eQTLs) and Cell type specific eQTLs (ct-eQTLs) were derived from blood and brain from participants of the Framingham Heart Study (blood, n=5257) and ROSMAP Study (brain, n=475) for AD loci established by published GWAS and linkage studies of AD and AD-related traits, as well as by other experimental approaches. Ct-eQTL analysis identified 11,649 and 2533 additional significant gene-SNP eQTL pairs in brain and blood, respectively, that were not detected in generic eQTL analysis. Of note, 386 unique target eGenes of significant eQTLs shared between blood and brain were enriched in apoptosis and Wnt signaling pathways. Five of these shared genes are established AD loci.
Available Filesets
| Name | Accession | Latest Release | Description |
|---|---|---|---|
| AD cell-type–specific eQTLs (blood & brain) (open access) | fsa000170 | NG00120.v1 | eQTL Summary Statistics |
View the File Manifest for a full list of files released in this dataset.