Description

This study investigated AD-related gene expression patterns in blood and brain cells types. A genome-wide cis ct-eQTL analysis was performed in blood and brain tissue donated by participants of the Framingham Heart Study and ROSMAP study, respectively. eQTLs and cell-type-specific eQTLs (ct-eQTLs) were compared between brain and blood with a focus on genes, loci, and cell types previously implicated in AD risk by genetic approaches.

Principal Investigators

  • Lindsay Farrer — Boston University School of Medicine
  • Xiaoling Zhang — Boston University School of Medicine

Funding Sources

RF1-AG057519, 2R01-AG048927, U01-AG058654, P30-AG13846, 3U01-AG032984, U01-AG062602, U19-AG068753

Publications

  • Patel D. Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue. Translational psychiatry. 2021 Apr 27. PubMed link