This study investigated AD-related gene expression patterns in blood and brain cells types. A genome-wide cis ct-eQTL analysis was performed in blood and brain tissue donated by participants of the Framingham Heart Study and ROSMAP study, respectively. eQTLs and cell-type-specific eQTLs (ct-eQTLs) were compared between brain and blood with a focus on genes, loci, and cell types previously implicated in AD risk by genetic approaches.