The Framingham Heart Study, under the direction of the National Heart, Lung and Blood Institute (NHLBI), formerly known as the National Heart Institute, has been committed to identifying the common factors or characteristics that contribute to cardiovascular disease (CVD) since its beginning in 1948. FHS has followed CVD development over…
Cohort Category: ADSP
Chicago Health and Aging Project (CHAP)
The Chicago Healthy Aging Project (CHAP) is a longitudinal population study of an urban general population sample (n= 10,000+) lasting from 1993 to 2012 of common chronic health problems of older persons, especially of risk factors for incident Alzheimer’s disease, based in three neighborhoods on the south side of Chicago. …
Cardiovascular Health Study (CHS)
The Cardiovascular Health Study (CHS) is an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older (n=5888, including a secondary cohort of predominately African-American subjects (n=687)). Starting in 1989, and continuing through 1999, participants underwent annual extensive clinical examinations. Measurements included traditional risk factors…
Austrian Stroke Prevention Survey (ASPS)
The Austrian Stroke Prevention Study is a community-based cohort study on the effects of vascular risk factors on brain structure and function in elderly participants without a history or signs of stroke and dementia on the inhabitants of Graz, Austria. 8193 individuals aged 50 to 75 years, stratified by sex…
Atherosclerosis Risk in Communities (ARIC)
The Atherosclerosis Risk in Communities Study (ARIC), sponsored by the National Heart, Lung, and Blood Institute (NHLBI) is a prospective epidemiologic study conducted in four U.S. communities. ARIC is designed to investigate the causes of atherosclerosis and its clinical outcomes, and variation in cardiovascular risk factors, medical care, and disease…
Progressive Supranuclear Palsy (PSP)
Patients with a clinical Parkinsonism in life and neuropathological confirmation of Progressive Supranuclear Palsy (PSP) were identified from brain banks, research hospitals and neuropathologists. The top three contributing sites were the Mayo Clinic, Harvard Brain Tissue Resource Center at McClean Hospital, and the University of Pennsylvania and additional small numbers…
Adult Changes in Thought (ACT)
The Adult Changes in Thought (ACT) study is a longitudinal prospective cohort study that began in 1994. Participants are randomly selected from Seattle area members of Group Health aged 65 years or older. Participants are cognitively intact at study enrollment, defined operationally as a CASI (Cognitive Abilities Screening Instrument) score…
University of Miami (MIA)
Each affected individual met NINCDS-ADRDA criteria for probable or definite AD with age at onset greater than 60 years, as determined from specific probe questions within the clinical history provided by a reliable family informant or from documentation of significant cognitive impairment in the medical record. Cognitively healthy controls were…
Erasmus Rucphen Family (ERF)
A family-based cohort study that is embedded in the Genetic Research in Isolated Populations (GRIP) program in the South West of the Netherlands. The aim of this program was to identify genetic risk factors in the development of complex disorders. For the Erasmus Rucphen Family Study (ERF), 22 families that…
Washington Heights and Inwood Community Aging project (WHICAP)
Unrelated Nondemented (initially), 65 years of age or older including non‐Hispanic whites (32%), African Americans (28%), and Caribbean Hispanics from the Dominican Republic (44%). Assessments include: medical evaluation, cognitive testing, MRI, PET scan and biomarkers studies. For more information about this cohort, see the WHICAP study.