Case studies generated for members of this cohort include clinical data regarding onset and progression of cognitive problems, medical history and medications, family history of memory problems, neurological history and examination results, psychiatric history and examination results, neuropsychological examination results, and diagnostic imaging and laboratory results. In addition to demographic…
Cohort Country: United States of America
Multi-Institutional Research in Alzheimer’s Genetic Epidemiology (MIRAGE)
The Multi-Institutional Research in Alzheimer’s Genetic Epidemiology (MIRAGE) Study is a family study funded by the NIA that began in 1991. The goal of MIRAGE is to identify genetic and non-genetic risk factors for Alzheimer’s disease. Approximately 2,500 members of 1,000 Caucasian and African American families were recruited and blood…
Minority Aging Research Study (MARS)
The Minority Aging Research Study (MARS) is a longitudinal, epidemiological cohort study of decline in cognitive function and risk of Alzheimer’s disease in older African-Americans. MARS began in 2004 and over 600 persons have enrolled, 560 of which are currently alive. The study enrolls African-American men and women over age…
Mayo Clinic (MAYO)
All 248 cases and 98 controls consisted of Caucasian subjects from the United States ascertained at the Mayo Clinic. All subjects were diagnosed by a neurologist at the Mayo Clinic in Jacksonville, Florida or Rochester, Minnesota. The neurologist confirmed a Clinical Dementia Rating score of 0 for all controls; cases…
Knight Alzheimer’s Disease Research Center (KGAD)
The search for novel risk factors for Alzheimer disease relies on access to accurate and deeply phenotyped datasets. The Memory and Aging Project at the Knight-ADRC (Knight ADRC-MAP) collects plasma, CSF, fibroblast, neuroimaging clinical and cognition data longitudinally and autopsied brain samples. We are using multi-tissue (brain, CSF and plasma)…
Genetic Differences (GenDiff)
Genetic Differences (GenDiff) was an epidemiologic case control study. Cases (235) were newly recognized (e.g., “incident”) “Probable AD” (McKhann criteria NINCDS-ADRDA). Subjects were discovered and diagnosed by the Alzheimer’s Disease Patient Registry from a community based HMO. Controls were selected at random from the same HMO, without cognitive impairment, and…
Genetic and Environmental Risk Factors for Alzheimer’s Disease Among African Americans (GenerAAtions)
Participants of the GenerAAtions Study were identified through the electronic claims database of the Henry Ford Health System. Community-dwelling African Americans aged 65 and older who had at least one encounter with the Henry Ford Health System in the three years prior to their recruitment and who had an available…
Framingham Heart Study (FHS)
The Framingham Heart Study, under the direction of the National Heart, Lung and Blood Institute (NHLBI), formerly known as the National Heart Institute, has been committed to identifying the common factors or characteristics that contribute to cardiovascular disease (CVD) since its beginning in 1948. FHS has followed CVD development over…
Chicago Health and Aging Project (CHAP)
The Chicago Healthy Aging Project (CHAP) is a longitudinal population study of an urban general population sample (n= 10,000+) lasting from 1993 to 2012 of common chronic health problems of older persons, especially of risk factors for incident Alzheimer’s disease, based in three neighborhoods on the south side of Chicago. …
Cardiovascular Health Study (CHS)
The Cardiovascular Health Study (CHS) is an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older (n=5888, including a secondary cohort of predominately African-American subjects (n=687)). Starting in 1989, and continuing through 1999, participants underwent annual extensive clinical examinations. Measurements included traditional risk factors…