Cohort Country: United States of America

The Minority Aging Research Study (MARS) is a longitudinal, epidemiological cohort study of decline in cognitive function and risk of Alzheimer’s disease in older African-Americans.  MARS began in 2004 and over 600 persons have enrolled, 560 of which are currently alive.  The study enrolls African-American men and women over age…

All 248 cases and 98 controls consisted of Caucasian subjects from the United States ascertained at the Mayo Clinic. All subjects were diagnosed by a neurologist at the Mayo Clinic in Jacksonville, Florida or Rochester, Minnesota. The neurologist confirmed a Clinical Dementia Rating score of 0 for all controls; cases…

The search for novel risk factors for Alzheimer disease relies on access to accurate and deeply phenotyped datasets. The Memory and Aging Project at the Knight-ADRC (Knight ADRC-MAP) collects plasma, CSF, fibroblast, neuroimaging  clinical and cognition data longitudinally and autopsied brain samples. We are using multi-tissue (brain, CSF and plasma)…

Genetic Differences (GenDiff) was an epidemiologic case control study. Cases (235) were newly recognized (e.g., “incident”) “Probable AD” (McKhann criteria NINCDS-ADRDA).  Subjects were discovered and diagnosed by the Alzheimer’s Disease Patient Registry from a community based HMO. Controls were selected at random from the same HMO, without cognitive impairment, and…

Participants of the GenerAAtions Study were identified through the electronic claims database of the Henry Ford Health System. Community-dwelling African Americans aged 65 and older who had at least one encounter with the Henry Ford Health System in the three years prior to their recruitment and who had an available…

The Framingham Heart Study, under the direction of the National Heart, Lung and Blood Institute (NHLBI), formerly known as the National Heart Institute, has been committed to identifying the common factors or characteristics that contribute to cardiovascular disease (CVD) since its beginning in 1948. FHS has followed CVD development over…

The Chicago Healthy Aging Project (CHAP) is a longitudinal population study of an urban general population sample (n= 10,000+) lasting from 1993 to 2012 of common chronic health problems of older persons, especially of risk factors for incident Alzheimer’s disease, based in three neighborhoods on the south side of Chicago. …

The Cardiovascular Health Study (CHS) is an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older (n=5888, including a secondary cohort of predominately African-American subjects (n=687)). Starting in 1989, and continuing through 1999, participants underwent annual extensive clinical examinations. Measurements included traditional risk factors…

The Atherosclerosis Risk in Communities Study (ARIC), sponsored by the National Heart, Lung, and Blood Institute (NHLBI) is a prospective epidemiologic study conducted in four U.S. communities.  ARIC is designed to investigate the causes of atherosclerosis and its clinical outcomes, and variation in cardiovascular risk factors, medical care, and disease…