The Multi-Institutional Research in Alzheimer’s Genetic Epidemiology (MIRAGE) Study is a family study funded by the NIA that began in 1991. The goal of MIRAGE is to identify genetic and non-genetic risk factors for Alzheimer’s disease. Approximately 2,500 members of 1,000 Caucasian and African American families were recruited and blood was collected for DNA and cell lines. These families included both subjects who are cognitively normal and others meeting NINCDS/ADRDA criteria for probable or definite AD. Subjects were ascertained at 17 centers in the US, Canada, Germany and Greece.