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Description

The 90+ Study was initiated in 2003 to study the oldest-old, the fastest growing age group in the United States. The 90+ Study is one of the largest studies of the oldest-old in the world. More than 1,600 people have enrolled. Initial participants in The 90+ Study were once members of The Leisure World Cohort Study (LWCS), which was started in 1981. The 90+ sample set was genotyped at the Children’s Hospital of Philadelphia using the Illumina Infinium GSAMD-24v2-0_20024620_A1 BeadChip which captures genotype data on 759,993 genomic SNPs. The standard Alzheimer’s Disease Genetics Consortium (ADGC) quality control pipeline (Naj et al. 2011) was applied to this GWAS dataset. The first release (February 4, 2021) includes quality controlled GWAS data on 268 participants from the 90+ cohort. It also includes minimal phenotypes provided by the 90+ Study and covariates provided by the Alzheimer’s Disease Genetics Consortium (ADGC). The final QC’d dataset contains 733,861 SNPs and 268 samples.

Sample Summary per Data Type

Sample SetAccessionData TypeNumber of Samples
90+ GWAS GSA snd10026GWAS268

Available Filesets

NameAccessionLatest ReleaseDescription
90+ Studyfsa000019NG00104.v1GWAS Data, Phenotypes, etc.

View the File Manifest for a full list of files released in this dataset.

The 90+ sample set was genotyped at the Children's Hospital of Philadelphia using the Illumina Infinium GSAMD-24v2-0_20024620_A1 BeadChip which captures genotype data on 759,993 genomic SNPs. The standard Alzheimer's Disease Genetics Consortium (ADGC) quality control pipeline (Naj et al. 2011) was applied to this GWAS dataset. The final QC'd dataset contains 733,861 SNPs and 268 samples.

Sample SetAccession NumberNumber of Subjects
90+ GWAS GSA snd10026268
Consent LevelNumber of Subjects
GRU-IRB-PUB268

Visit the Data Use Limitations page for definitions of the consent levels above.

Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

Use the study-specific acknowledgement statements below (as applicable):

For investigators using any data from this dataset:

Please cite/reference the use of NIAGADS data by including the accession NG00104.

For investigators using (sa000020) data:

The 90+ Study receives support through a National Institute on Aging (NIA) grant R01AG21055. We thank the staff and investigators of the study as well as the participants and their families, whose help and participation made this work possible.

Quality control procedures and data preparation on the GWAS was conducted by the Alzheimer’s Disease Genetics Consortium (ADGC) (UO1AG032984) and the NIA Genetics of Alzheimer’s Disease Storage Site (NIAGADS) (U24-AG041689), both funded by NIA.  

  • Corrada MM, Brookmeyer R, Paganini-Hill A, Berlau D, Kawas CH. Dementia incidence continues to increase with age in the oldest-old: The 90+ Study. Ann Neurol. 2010 Jan. doi: 10.1002/ana.21915 PubMed link
  • Corrada MM, Berlau DJ, Kawas CH. A population-based clinicopathological study in the oldest-old: the 90+ study. Curr Alzheimer Res. 2012 Jul. doi: 10.2174/156720512801322537 PubMed link
  • Corrada MM, Paganini-Hill A, Berlau DJ, Kawas CH. Apolipoprotein E genotype, dementia, and mortality in the oldest old: The 90+ Study. Alzheimers Dement. 2013 Jan. doi: 10.1016/j.jalz.2011.12.004 PubMed link