The 90+ Study was initiated in 2003 to study the oldest-old, the fastest growing age group in the United States. The 90+ Study is one of the largest studies of the oldest-old in the world. More than 1,600 people have enrolled. Initial participants in The 90+ Study were once members of The Leisure World Cohort Study (LWCS), which was started in 1981. Participants of The 90+ Study are visited every six months by researchers who perform neurological and neuropsychological tests. Our researchers at the Clinic for Aging Research and Education (CARE), located in Laguna Woods, obtain information about diet, activities, medical history, medications and numerous other factors. Additionally, participants are given a series of cognitive and physical tests to determine how well people in this age group are functioning.

Claudia Kawa, MD
University of California Irvine

Maria Corrada, Sc.D.
University of California Irvine

R01AG21055 and U24AG021886

Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

For investigators using data:

The 90+ Study receives support through a National Institute on Aging (NIA) grant R01AG21055. We thank the staff and investigators of the study as well as the participants and their families, whose help and participation made this work possible.

Quality control procedures and data preparation on the GWAS was conducted by the Alzheimer’s Disease Genetics Consortium (ADGC) (UO1AG032984) and the NIA Genetics of Alzheimer’s Disease Storage Site (NIAGADS) (U24-AG041689), both funded by NIA.  

  • Corrada MM, Brookmeyer R, Paganini-Hill A, Berlau D, Kawas CH. Dementia incidence continues to increase with age in the oldest-old: The 90+ Study. Ann Neurol. 2010 Jan. doi: 10.1002/ana.21915 PubMed link
  • Corrada MM, Berlau DJ, Kawas CH. A population-based clinicopathological study in the oldest-old: the 90+ study. Curr Alzheimer Res. 2012 Jul. doi: 10.2174/156720512801322537 PubMed link
  • Corrada MM, Paganini-Hill A, Berlau DJ, Kawas CH. Apolipoprotein E genotype, dementia, and mortality in the oldest old: The 90+ Study. Alzheimers Dement. 2013 Jan. doi: 10.1016/j.jalz.2011.12.004 PubMed link