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Description

In 2018, 960 respondents from LASI-DAD who consented to the blood sample collection have been genotyped using Illumina Infinium genotyping platforms. The datasets being submitted include the original genotype assayed by the genotyping platforms, imputed data to the 1000G reference panel, as well as imputed data to the TOPMed reference panel. The first dataset is the genotype data assayed by the Illumina Infinium Global Screening Array-24 v2.0 BeadChip. It contains 1008 scans derived from 993 unique subjects (including 960 LASI-DAD subjects and 33 1000G control subjects) and is in PLINK format. The second dataset contains the imputed data to the 1000G reference panel (phase 3 v5) and is in vcf format. It contains 960 unique LASI-DAD subjects. The third dataset contains the imputed data to the TOPMed reference panel (r2) and is in vcf format. It contains 960 unique LASI-DAD subjects.

Sample Summary per Data Type

Sample SetAccessionData TypeNumber of Samples
LASI-DAD GWAS GSA snd10023GWASn = 1008

Available Filesets

NameAccessionLatest ReleaseDescription
LASI-DAD – GWAS Datafsa000011NG00106.v1GWAS Data
LASI-DAD - 1000G Imputed Datafsa000012NG00106.v11000G Imputed Data
LASI-DAD - TOPMed Imputed Datafsa000013NG00106.v1TopMed Imputed Data
LASI-DAD Association Results, Phenotypes, etc.fsa000014NG00106.v1Association Results, Phenotypes, etc.

View the File Manifest for a full list of files released in this dataset.

The dataset contains 1008 scans derived from 993 unique subjects (including 960 LASI-DAD subjects and 33 1000G control subjects) and is in PLINK format. The DNA samples were genotyped at MedGenome Inc. using the Illumina Infinium Global Screening Array-24 v2.0 BeadChip.

Sample SetAccession NumberNumber of Subjects
LASI-DAD GWAS GSAsnd10023n = 993
Consent LevelNumber of Subjects
GRU-IRB-PUBn = 993

Visit the Data Use Limitations page for definitions of the consent levels above.

Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

Use the study-specific acknowledgement statements below (as applicable):

For investigators using any data from this dataset:

Please cite/reference the use of NIAGADS data by including the accession NG00106.

For investigators using LASI-DAD (sa000019) data:

In text: "The Longitudinal Aging Study in India, Diagnostic Assessment of Dementia data is sponsored by the National Institute on Aging (grant number R01AG051125, RF1AG055273, U01AG065958) and is conducted by the University of Southern California."

In references: "The Longitudinal Aging Study in India, Diagnostic Assessment of Dementia Study. Produced and distributed by the University of Southern California with funding from the National Institute on Aging (grant number R01AG051125, RF1AG055273, U01AG065958), Los Angles, CA."

  • Lee J, Dey AB. Introduction to LASI-DAD: The Longitudinal Aging Study in India-Diagnostic Assessment of Dementia. J Am Geriatr Soc. 2020 Aug;68 Suppl 3(Suppl 3):S3-S4. doi: 10.1111/jgs.16740. PMID: 32815600; PMCID: PMC7513796. PubMed link
  • Lee J, Khobragade PY, Banerjee J, Chien S, Angrisani M, Perianayagam A, Bloom DE, Dey AB. Design and Methodology of the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD). J Am Geriatr Soc. 2020 Aug;68 Suppl 3(Suppl 3):S5-S10. doi: 10.1111/jgs.16737. PMID: 32815602; PMCID: PMC7503220. PubMed link
  • Smith JA, Zhao W, Yu M, Rumfelt KE, Moorjani P, Ganna A, Dey AB, Lee J, Kardia SLR. Association Between Episodic Memory and Genetic Risk Factors for Alzheimer’s Disease in South Asians from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD). J Am Geriatr Soc. 2020 Aug;68 Suppl 3(Suppl 3):S45-S53. doi: 10.1111/jgs.16735. PMID: 32815605; PMCID: PMC7507858. PubMed link