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Within the application, add this dataset (accession NG00129) in the “Choose a Dataset” section.
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Description

This ADSP release, containing 170 whole-exomes includes 1) sequencing read alignments in CRAM (compressed BAM) format for the newly sequenced 170 samples, (2) genomic Variant Call Format (gVCF) files generated by GATK4.1.1 on samples.
The pVCF released here is provided as a preview to the formal ADSP quality control that will be released in a few months. Checks of the dataset are ongoing, and the released files may be subject to change in the full quality-controlled release.

Sample Summary per Data Type

Sample SetAccessionData TypeNumber of Samples
NCRAD Families WESsnd10039WES170

Available Filesets

FilesetAccessionLatest ReleaseDescription
NCRAD Families WES CRAMs and GATK gVCFsfsa000037NG00129.v1WES CRAMs and GATK gVCFs. Sequencing Data Quality Control Metrics
NCRAD Families Phenotype and Manifest Filesfsa000038NG00129.v1Phenotypes for sequenced subjects and connecting family members
NCRAD Families WES Project Level VCFfsa000039NG00129.v1Preview pVCF

View the File Manifest for a full list of files released in this dataset.

This dataset includes WES data on 170 sequenced subjects. Phenotype data also includes connecting family data for the sequenced subjects.

Sample SetAccessionNumber of Subjects
NCRAD Families WESsnd10039170

This release includes whole exome CRAMs, gVCFs, preview pVCFs, and phenotypes for 170 NCRAD Families samples.

NCRAD Families Whole Exome Sequencing (WES) Preview
This ADSP release, containing 170 whole-exomes includes 1) sequencing read alignments in CRAM (compressed BAM) format for the newly sequenced 170 samples, (2) genomic Variant Call Format (gVCF) files generated by GATK4.1.1 on samples.
The pVCF released here is provided as a preview to the formal ADSP quality control that will be released in a few months. Checks of the dataset are ongoing, and the released files may be subject to change in the full quality-controlled release.

Consent LevelNumber of Subjects
GRU-IRB-PUB170

Visit the Data Use Limitations page for definitions of the consent levels above.

Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

Use the study-specific acknowledgement statements below (as applicable):

For investigators using any data from this dataset:

Please cite/reference the use of NIAGADS data by including the accession NG00129.

For investigators using NCRAD Family Study (sa000025) data:

Samples from the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD), which receives government support under a cooperative agreement grant (U24AG021886) awarded by the National Institute on Aging (NIA), were used in this study. We thank the participants and their families, whose help and participation made this work possible.

For use of data in ng00117: Quality control procedures and data preparation on the GWAS was conducted by the Alzheimer’s Disease Genetics Consortium (ADGC) (UO1AG032984) and the NIA Genetics of Alzheimer’s Disease Storage Site (NIAGADS) (U24-AG041689), both funded by NIA.

For use of data in ng00129: Data processing and quality control procedures on the whole-exome dataset was conducted by the Genome Center for Alzheimer’s Disease (GCAD) (U54AG052427) and the NIA Genetics of Alzheimer’s Disease Storage Site (NIAGADS) (U24-AG041689), both funded by NIA.