To access this data, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00132) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.

Description

The APOE and Serotonin Transporter Alleles data product includes data for the APOE isoform, directly genotyped using a TaqMan allelic discrimination SNP assay, where available, or imputed from preexisting genotype array data otherwise. This file also includes human serotonin transporter (5HTTLPR) short and long alleles measured using polymerase chain reaction (PCR). In total, there are 19,193 HRS participants in the data file: 17,237 with directly genotyped data for APOE and 1,956 additional participants with imputed data. There are 17,364 participants with valid values for 5HTTLPR.

Genotype data for HRS subjects is available at NG00119 – Health and Retirement Study Genotype Data 2006-2012, and DNA methylation data for HRS subjects is available at NG00153 – Health and Retirement Study (HRS) DNA Methylation. To obtain subject ID mapping between HRS datasets, please submit a Genetic Data Cross-Reference Request Form on the HRS website.

Sample Summary per Data Type

Sample SetAccessionData TypeNumber of Samples
HRS APOEsnd10040Targeted genotyping19,193

Available Filesets

NameAccessionLatest ReleaseDescription
HRS APOE: Targeted genotype datafsa000040NG00132.v1Targeted genotype data

View the File Manifest for a full list of files released in this dataset.