Description
Data Available
To access this data, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00132) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.
Description
The APOE and Serotonin Transporter Alleles data product includes data for the APOE isoform, directly genotyped using a TaqMan allelic discrimination SNP assay, where available, or imputed from preexisting genotype array data otherwise. This file also includes human serotonin transporter (5HTTLPR) short and long alleles measured using polymerase chain reaction (PCR). In total, there are 19,193 HRS participants in the data file: 17,237 with directly genotyped data for APOE and 1,956 additional participants with imputed data. There are 17,364 participants with valid values for 5HTTLPR.
Sample Summary per Data Type
| Sample Set | Accession | Data Type | Number of Samples |
|---|---|---|---|
| HRS APOE | snd10040 | Targeted genotyping | 19,193 |
Available Filesets
| Name | Accession | Latest Release | Description |
|---|---|---|---|
| HRS APOE: Targeted genotype data | fsa000040 | NG00132.v1 | Targeted genotype data |
View the File Manifest for a full list of files released in this dataset.
Subject Information
Provided in this dataset is a csv file containing APOE genotypes and HTTLPR calls for 19,193 total subjects. 17,237 subjects’ APOE genotypes were collected directly using a TaqMan allelic discrimination SNP assay at the Center for Inherited Disease Research (CIDR) Genetic Resources Core Facility (GRCF) and Fragment Analysis Facility (FAF) at Johns Hopkins University. 1,956 subjects’ APOE genotypes were imputed from a preexisting genotype array to the 1000G (Phase3 v5) reference panel. 17,364 subjects’ HTTLPR short and long alleles were measured using PCR.
| Sample Set | Accession Number | Number of Subjects |
|---|---|---|
| HRS APOE | snd10040 | 19,193 |
Related Studies
Consent Levels
| Consent Level | Number of Subjects |
|---|---|
| GRU-IRB-PUB-NPU | 19,193 |
Visit the Data Use Limitations page for definitions of the consent levels above.
Acknowledgement
Acknowledgment statement for any data distributed by NIAGADS:
Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.
Use the study-specific acknowledgement statements below (as applicable):
For investigators using any data from this dataset:
Please cite/reference the use of NIAGADS data by including the accession NG00132.
For investigators using HRS (sa000021) data:
HRS is supported by the National Institute on Aging (NIA U01AG009740). The genotyping was partially funded by separate awards from NIA (RC2 AG036495 and RC4 AG039029). Our genotyping was conducted by the NIH Center for Inherited Disease Research (CIDR) at Johns Hopkins University. Genotyping quality control and final preparation were performed by the Genetics Coordinating Center at University of Washington (Phases 1-3) and the University of Michigan (Phase 4).