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Description

This dataset includes individual level data from Sacramento Area Longitudinal Study on Aging (SALSA). This includes both genotyping (raw and imputed) on the Infinium Global Screening Array-24 Kit as well as phenotypic data including age, sex, prevalent dementia, incident dementia, and time of follow-up. There were total of 1,788 subjects that were enrolled in the study and 1316 subjects passed QC filtering.

The SALSA study is tracking the incidence of physical and cognitive impairment as well as dementia and cardiovascular diseases in elderly Latinos in the Sacramento region. The effects of hypertension, diabetes, and other cardiovascular risk factors, such as nutrition and lifestyle factors, are also being examined. The SALSA study aims to: (1) assess cognitive, physical and social functions, which include the ability to follow instructions, to perform certain movements, and to interact with others, (2) examine the effect that cultural, nutritional, social and cardiovascular risk factors have on overall health and dementia, (3) examine the association between diabetes and functional status, and (4) estimate the prevalence and incidence of dementia in the Latino population in the Sacramento area.

Sample Summary per Data Type

Sample SetAccessionData TypeNumber of Samples
SALSA GWAS snd10090Genotyping SNP Array and Imputation1,788

Available Filesets

NameAccessionLatest ReleaseDescription
SALSA GWAS: Genotype, Phenotype and Imputation datafsa000113NG00141.v1Genotype, Phenotype and Imputation data

View the File Manifest for a full list of files released in this dataset.

For more demographic information about the subjects, navigate to the sample set below.

Sample SetAccession NumberNumber of SubjectsNumber of Samples
SALSA GWASsnd100901,7881,788
Consent LevelNumber of Subjects
DS-ND-IRB-PUB1,788

Visit the Data Use Limitations page for definitions of the consent levels above.

Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

Use the study-specific acknowledgement statements below (as applicable):

For investigators using any data from this dataset:

Please cite/reference the use of NIAGADS data by including the accession NG00141.

For investigators using The Sacramento Area Latino Study on Aging (sa000055) data:

This study is funded by NIHAG052409, titled “ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model Systems”.

Martinez-Miller  EE., et al. Acculturation, cognitive performance and decline, and incident dementia/CIND: The Sacramento Area Latino Study on Aging. American Journal of Epidemiology. 2020 May 22. doi: 10.1093/aje/kwaa088. Pubmed Link

Miller JW., et al. Homocysteine and cognitive function in the Sacramento Area Latino Study on Aging. American Journal of Clinical Nutrition.2003 Sep. doi: 10.1093/ajcn/78.3.441. Pubmed Link

Shih IF., et al. Physical activity modifies the influence of apolipoprotein E ε4 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans. Alzheimers Dement. 2018. doi:10.1016/j.jalz.2017.05.005. Pubmed Link

Mungas D., et al. Education, bilingualism, and cognitive trajectories: Sacramento Area Latino Aging Study (SALSA). Neuropsychology. 2018. doi:10.1037/neu0000356.Pubmed Link

Hinton L., et al. Neuropsychiatric Symptoms in Latino Elders With Dementia or Cognitive Impairment Without Dementia and Factors That Modify Their Association With Caregiver Depression. The Gerontologist. October 2003. doi: 10.1093/geront/43.5.669. Pubmed Link