Description
Data Available
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Within the application, add this dataset (accession NG00154) in the “Choose a Dataset” section.
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Description
One of the most common Alzheimer’s Disease Related Dementias (ADRD) is Lewy body dementia. This umbrella term comprises two clinically distinct ADRDs: Parkinson’s disease dementia (PD-dementia) and dementia with Lewy bodies (DLB). There has been a growing interest in the genetic bases of DLB, however, PD-dementia has not yet been studied using large-scale genetic analyses. Nevertheless, it has been shown that dysfunction of the endolysosomal pathway plays a key role in Alzheimer’s disease and ADRDs. This involvement, however, is not fully understood and the exact failure points for each disease have yet to be identified. Thus, there is a gap in knowledge regarding the specific molecular mechanisms underlying each disease.
This dataset includes Genotyping SNP Array data individually in IDAT files, together in a processed VCF, and includes phenotype data for the 292 PD samples from USA and Portugal.
Sample Summary per Data Type
| Sample Set | Accession | Data Type | Number of Samples |
|---|---|---|---|
| Dementia in Parkinson's Disease (PDD) | snd10049 | Genotyping SNP array | 292 |
Available Filesets
| Name | Accession | Latest Release | Description |
|---|---|---|---|
| PDD Genotype and Phenotype files | fsa000067 | NG00154.v1 | Phenotype, IDAT and VCF files for Genotyping SNP Array. |
View the File Manifest for a full list of files released in this dataset.
Subject Information
This dataset contains data from 292 subjects that were genotyped using the Infinium™ Global Screening Array-24 v3.0 BeadChip. In addition to a processed VCF file with all 292 samples, the dataset also includes a green and a red raw IDAT file for each subject (total of 584 IDAT files).
| Sample Set | Accession Number | Number of subjects |
|---|---|---|
| Dementia in Parkinson's Disease (PDD) | snd10049 | 292 |
Related Studies
Consent Levels
| Consent Level | Number of Subjects |
|---|---|
| DS-ND-IRB-PUB | 292 |
Visit the Data Use Limitations page for definitions of the consent levels above.
Acknowledgement
Acknowledgment statement for any data distributed by NIAGADS:
Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.
Use the study-specific acknowledgement statements below (as applicable):
For investigators using any data from this dataset:
Please cite/reference the use of NIAGADS data by including the accession NG00154.
For investigators using Dementia in Parkinson's Disease (sa000038) data:
The American cohort of samples for this project was collected by Dr. Cyrus Zabetian and Dora Yearout at VA Puget Sound. The Portuguese cohort was collected by Dr. Ana Morgadinho. Drs. Rita Guerreiro and Jose Bras as well as Kimberly Paquette, Kaitlyn Westra, and Andrew Pyman were involved in preparing the data. This work was supported by grant funding from NIH R56 AG070857. The author(s) thank the Van Andel Institute Genomics Core (RRID:SCR_022913) (Grand Rapids, MI) for providing whole-genome genotyping facilities and services.