Description
Whole Genome Sequencing Data
In July 2012, the Brin-Wojcicki Foundation and the Alzheimer’s Association donated funds to support whole genome sequencing (WGS) of 818 ADNI participants (at the time: 128 with AD, 415 with MCI, 267 controls and 8 of uncertain diagnosis). Samples were sent to Illumina, where non-CLIA WGS, as well as Illumina Omni 2.5M genome-wide association study (GWAS) single nucleotide polymorphism (SNP) arrays, were performed on each sample and completed in Spring 2013.
The samples were sequenced on the Illumina HiSeq 2000 platform with 100bp paired-end reads.
Information obtained from the ADNI website on August 28, 2018.
Sex
Total number of samples: 809
Female 363 44.9 %
Male 446 55.1 %
Race
Total number of samples: 809
| American Indian/Alaska Native | 2 |
| Asian | 10 |
| Native Hawaiian or Other Pacific Islander | 2 |
| Black or African American | 28 |
| White | 757 |
| Other | 10 |
Ethnicity
Total number of samples: 809
Not Hispanic or Latino
785
97.0%
Hispanic or Latino
19
2.3%
Not Applicable/Not Available
5
0.6%
Diagnosis
Total number of samples: 810
| AD | ||
|---|---|---|
| Control | 249 | 30.7% |
| Case | 239 | 29.5% |
| Other | 322 | 39.8% |
APOE
Total number of samples: 809
- 221 (0.1%)
- 2370 (8.7%)
- 2415 (1.9%)
- 33406 (50.2%)
- 34260 (32.1%)
- 4457 (7.0%)