Whole Genome Sequencing Data

In July 2012, the Brin-Wojcicki Foundation and the Alzheimer’s Association donated funds to support whole genome sequencing (WGS) of 818 ADNI participants (at the time: 128 with AD, 415 with MCI, 267 controls and 8 of uncertain diagnosis). Samples were sent to Illumina, where non-CLIA WGS, as well as Illumina Omni 2.5M genome-wide association study (GWAS) single nucleotide polymorphism (SNP) arrays, were performed on each sample and completed in Spring 2013.

The samples were sequenced on the Illumina HiSeq 2000 platform with 100bp paired-end reads.

Information obtained from the ADNI website on August 28, 2018.

Total number of samples: 809

Female 363 44.9 %
Male 446 55.1 %

Total number of samples: 809

American Indian/Alaska Native2
Asian10
Native Hawaiian or Other Pacific Islander2
Black or African American28
White756
Other11

Total number of samples: 809

Not Hispanic or Latino
784
96.9%
Hispanic or Latino
19
2.3%
Not Applicable/Not Available
6
0.7%

Total number of samples: 809

Disease
AD809100.0%
Study Specific Diagnosis
Control24930.8%
Case23829.4%
Other32239.8%

Total number of samples: 809

  • 221 (0.1%)
  • 2370 (8.7%)
  • 2415 (1.9%)
  • 33404 (49.9%)
  • 34260 (32.1%)
  • 4457 (7.0%)
  • NA2 (0.2%)