Progressive supranuclear palsy samples were sequenced at FGC, IDOM and PGFI at University of Pennsylvania on the HiSeq2000/2500 machine.  705 samples were sequenced using Roche Nimblegen’s VCRome v2.1, target capture kit. BAM files from hg37 build and FASTQ files were sent to GCAD for processing on the VCPA1.1 pipeline. 549 passed sequencing metrics and quality control.