AMP-AD samples from the ROSMAP, MayoRNAseq, and Mount Sinai Brain Bank cohorts were whole-genome sequenced at New York Genome Center on the HiSeqX machine. FASTQ files were sent to GCAD for processing on the VCPA1.1 pipeline. 1326 samples passed sequencing metrics and quality control. Additional information about each of the three studies can be obtained from the AMP-AD Knowledge Portal.