Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with many biological processes, and molecular changes. The etiology of AD is complex and not specific to a single genetic factor. Epigenetic changes could help explain the missing heritability not capture in GWAS chips and determine functional variants in genome-wide significant loci. DNA methylation data from 431 parietal lobe of AD and neuropath-free controls was generated from the Knight-ADRC. The Illumina Infinium MethylationEPIC interrogates the methylation over 850,000 CpG and non-CpG sites, open chromatin, enhancers, DNase hypersensitive sites and promoters.