Description
Sample selection and genotyping was coordinated and paid for by the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD). NCRAD supported genotyping of samples from subjects with diagnoses other than AD, MCI, or cognitively normal. The ADC14 sample set was genotyped by the Center for Applied Genomics at the Children’s Hospital of Philadelphia using the Illumina Infinium Global Screening Array (GSAMD-24v2-0_20024620_A1) BeadChip which captures genotype data on 759,993 genomic SNPs. The standard Alzheimer’s Disease Genetics Consortium (ADGC) quality control pipeline (Naj et al. 2011) was applied to this GWAS dataset.
Sex
Total number of samples: 4,620
Female 2,290 49.6 %
Male 2,330 50.4 %
Race
Total number of samples: 4,620
| American Indian/Alaska Native | 5 |
| Asian | 139 |
| Native Hawaiian or Other Pacific Islander | 2 |
| Black or African American | 480 |
| White | 3,900 |
| Other | 94 |
Ethnicity
Total number of samples: 4,620
Not Hispanic or Latino
4,264
92.3%
Hispanic or Latino
336
7.3%
Not Applicable/Not Available
20
0.4%
Diagnosis
Total number of samples: 4,620
| AD | ||
|---|---|---|
| Control | 430 | 9.3% |
| Case | 225 | 4.9% |
| Unknown | 3,965 | 85.8% |
APOE
Total number of samples: 4,620
- 2221 (0.5%)
- 23469 (10.2%)
- 2495 (2.1%)
- 332,525 (54.7%)
- 341,283 (27.8%)
- 44226 (4.9%)
- NA1 (0.0%)