Description

Human post-mortem brain samples were obtained from the Netherlands Brain Bank (NBB) and the Neuropathology Brain Bank and Research CoRE at Mount Sinai Hospital. The permission to collect human brain material was obtained from the Ethical Committee of the VU University Medical Center, Amsterdam, The Netherlands, and the Mount Sinai Institutional Review Board. For the Netherlands Brain bank, informed consent for autopsy, the use of brain tissue and accompanied clinical information for research purposes was obtained per donor ante-mortem.

Principal Investigators

  • Towfique Raj — Icahn School of Medicine at Mount Sinai Hospital

Funding Sources

This work was supported by grants from the US National Institutes of Health (NIH NIA R21-AG063130, NIA R01- AG054005, NIA U01-AG068880, and NIA R56-AG055824). Research reported in this paper was supported by the Office of Research Infrastructure of the National Institutes of Health under award number S10OD026880.

Publications

  • Lopes KP. Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies. Nature genetics. 2022 Jan. PubMed link
  • Humphrey J. Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing. Nature genetics. 2025 Mar. PubMed link
  • Snijders GJLJ. The human microglia responsome: a resource for microglia states in health and disease. Brain, behavior, and immunity. 2025 Nov. PubMed link