We performed Whole-exome and Whole-Genome association analyses with Alzheimer’s disease risk in ADSP data (NG00067.v5), focusing on non-Hispanic white individuals of European ancestry. Specifically, we designed novel variant filters that account for variant frequency differences across sequencing centers/platforms in the ADSP data. Here, we share the related summary statistics from the Alzheimer’s disease risk association analyses, together with those from the primary Fisher exact tests used to assess cross-center/platform variant frequency differences, as well as relevant information from other gnomAD filters and duplicate sample filters that were implemented. Technical and analytical details regarding the filters and association models are detailed in the manuscript. ADSP WES analyses included 11,573 individuals (5,418 controls and 6,155 cases). ADSP WGS analyses included 6,533 individuals (2,949 controls and 3,584 cases). The p-value data is generally available to all users using the link below; however, gaining access to the complete dataset requires a formal data request.

Michael Greicius, MD, MPH
Stanford University

NIA (AG060747, AG047366, AG066206, AG066515)

Acknowledgment statement for any data distributed by NIAGADS:

Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer's Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.

For investigators using A fast and robust strategy to remove variant level artifacts in Alzheimer’s Disease Sequencing Project data (Belloy et al. 2022) data:

Funding for this study was provided by The Iqbal Farrukh & Asad Jamal Fund, the NIH (AG060747 and AG047366, granted to M.D.G, AG066206 and AG066515, granted to Z.H), the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie (grant agreement No. 890650, granted to Y.L.G.), and the Alzheimer’s Association (AARF-20-683984, granted to M.E.B).

  • Belloy ME. A fast and robust strategy to remove variant levels artifacts in Alzheimer’s Disease Sequencing Project data. Neurol Genet. 2022 Aug. doi: 10.1212/NXG.0000000000200012 PubMed link